Koselugo dosage: Form, strengths, how to take, and more
The dosage of Koselugo (selumetinib) for treating certain nerve tumors in children is based on body surface area. Dosing may vary due to medications they’re taking and other factors. It’s important that they take the prescribed dosage.
Koselugo is used to treat plexiform neurofibromas (PN) in children ages 2 years and older with a genetic disorder called neurofibromatosis type 1 (NF1). The drug comes as a capsule that your child usually takes twice daily.
The active ingredient in Koselugo is selumetinib. Koselugo belongs to a group of drugs called kinase inhibitors.
This article describes the dosage of Koselugo, as well as its strengths and how to take it.
Your child’s doctor will likely prescribe the smallest dosage that provides the desired effect. However, dosage is based on your child’s body surface area (BSA). This is a calculation, expressed in square meters (m2), based on your child’s height and weight.
Koselugo is available as an oral capsule.
Koselugo comes in two strengths: 10 milligrams (mg) and 25 mg.
The following table highlights the basics of Koselugo’s dosage to treat PN in children ages 2 years and older with neurofibromatosis type 1 (NF1). All doses are listed in milligrams (mg). Doses should be 12 hours apart.
Always be sure that your child takes the dosage their doctor prescribes. Your child’s doctor will determine the best dosage to fit their needs. In some cases, doctors may adjust the dosage from those shown here.
If your child experiences any side effects that may prevent them from taking the medication, notify their doctor.
Your child should take their doses of Koselugo approximately 12 hours apart. They should swallow the capsules whole with water and either with or without food. Be sure they do not chew the capsules or let them dissolve in their mouth. Also, be sure not to open the capsules.
Some children may not be able to swallow capsules. In this case or if your child has difficulty swallowing them, talk with your doctor or pharmacist.
If your child vomits after taking a dose, do not give them an extra dose. Instead, you should wait to give them their next dose at the usual time.
Koselugo is usually a long-term treatment. You and your child’s doctor can determine whether it’s safe and effective for your child. If you agree that it is, your child likely will take it long term. Typically, your child will continue Koselugo treatment until the disease progresses or side effects become difficult to tolerate.
Your child should not take more Koselugo than their doctor prescribes, as this can lead to harmful effects.
Call your child’s doctor right away if you think your child has taken too much Koselugo. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if your child has symptoms that seem severe, immediately call 911 (or your local emergency number). Or take them to the nearest emergency room.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.