Vyvgart Hytrulo: Side effects, warnings, and safety precautions
Vyvgart Hytrulo is a subcutaneous injection prescribed for certain autoimmune conditions. Common side effects include headache, respiratory infections, and injection site reactions.
Vyvgart Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) is a biologic drug used in adults with generalized myasthenia gravis (gMG) who are anti-AChR antibody positive, or for chronic inflammatory demyelinating polyneuropathy (CIDP).
Note: This article describes the side effects of Vyvgart Hytrulo, which is given as an injection under the skin. For information on side effects of Vyvgart — which is given as an intravenous (IV) infusion (an injection into a vein given over time) — see this Vyvgart side effects article.
Mild to moderate side effects are common in people receiving Vyvgart Hytrulo injections. The most frequently reported side effects in the drug’s clinical trials — occurring in 10% or more of people — include:
* These reactions were especially common in patients with CIDP, occurring in about 15% of cases.
There are several serious health issues you and your doctor should watch for during your Vyvgart Hytrulo treatment.
Vyvgart Hytrulo lowers your IgG antibody levels, which can make it harder for your body to fight infections.
Although it’s rare, some people can have a serious allergic reaction to this drug called anaphylaxis. This can occur during the injection, shortly after, or even weeks later. Symptoms can include hives, swelling of the face or throat, difficulty breathing, or a sudden drop in blood pressure that causes fainting.
Some people experience reactions shortly after their injection, such as high blood pressure, chills/shivering, and back, chest or abdominal pain.
Before starting Vyvgart Hytrulo treatment, there are several things you should discuss with your doctor.
You should be up-to-date on all recommended vaccines before starting a treatment cycle. It’s generally recommended that you avoid live vaccines during treatment with this medication.
It’s not known if Vyvgart Hytrulo can harm an unborn baby or pass into breast milk. If you’re pregnant or planning a pregnancy, your doctor can enroll you in a pregnancy registry to monitor your health and the health of your baby.
This medication may reduce the effectiveness of other drugs that rely on certain antibodies to work, such as monoclonal antibodies or other immunoglobulin therapies. Be sure that your doctor always has a
Tell your doctor if you have a history of kidney problems or severe allergic reaction to any of the ingredients in Vyvgart Hytrulo.
Disclaimer: While Medical News Today strives for factual, comprehensive, and current information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses. Learn more about our approach to content integrity.