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Xdemvy and dosage: Strength, form, when to use, and more

Medical News Today Published Oct 14, 2025 Reviewed Jun 30, 2026 ✓ Reviewed by citations.press editors
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The dosage of Xdemvy for Demodex blepharitis is typically 1 drop per eye twice daily for 6 weeks.
1 drop · dose2 per day · frequency6 weeks · duration
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Doses of Xdemvy should be applied approximately 12 hours apart.
12 hours · interval
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When using other topical eye medications, each medication should be applied at least 5 minutes apart.
5 minutes · interval
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If wearing contact lenses, they should be removed before applying Xdemvy and can be reinserted 15 minutes after application.
15 minutes · interval
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Xdemvy treatment typically lasts 6 weeks.
6 weeks · duration
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The dosage of Xdemvy (lotilaner ophthalmic solution) for Demodex blepharitis is typically 1 drop per eye twice daily for 6 weeks. It’s important to take the Xdemvy dosage your doctor prescribes.

Xdemvy is a prescription drug prescribed for adults to treat Demodex blepharitis. With this condition, your eyelids develop inflammation caused by Demodex mites.

The active ingredient in Xdemvy is lotilaner. Xdemvy belongs to a group of drugs called antiparasitics.

This article describes the dosage of Xdemvy, as well as its strength and how to use it. You can also review Xdemvy’s prescribing information for more details.

The following information describes dosages that are commonly used or recommended for Xdemvy. Be sure to take the dosage your doctor prescribes for you.

The recommended dosage for treating Demodex blepharitis is 1 drop in each eye twice daily.

Always follow your prescribing doctor’s instructions. Notify them if you experience any side effects that may prevent you from taking your medication.

Your doctor or pharmacist will advise you how to use Xdemvy. Typically, you’ll place 1 drop in each eye twice daily for 6 weeks. Apply your doses approximately 12 hours apart.

When also using other topical eye medications, apply each medication at least 5 minutes apart.

If you wear contact lenses, remove the lenses before applying Xdemvy. You may reinsert the contact lenses 15 minutes after applying your dose of Xdemvy.

If you miss applying a dose of Xdemvy, skip the missed dose. Then apply your next dose of Xdemvy at the scheduled time.

Xdemvy is typically prescribed for a limited time. Your doctor will determine your treatment plan, including how long you’ll use Xdemvy. Typically, Xdemvy treatment lasts 6 weeks.

Do not take more Xdemvy than your doctor prescribes, as this can lead to harmful effects.

If you think you’ve used too much Xdemvy, call your doctor right away. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have symptoms that feel severe, immediately call 911 or your local emergency number. Or go to the nearest emergency room.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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